- The Seahawks are 1.5-point road favourites. The total is 43.5 points.
- The Seahawks pummeled the New Orleans Saints 44-13 in Week 2.
- Cardinals quarterback Kyler Murray is 2-8 all-time against the Seahawks.
Kicking off Week 4 on Thursday Night Football, the 2-1 Arizona Cardinals will host the 2-1 Seattle Seahawks.
Despite being the road team, the Seahawks are 1.5-point favourites, which is tied for the second-lowest of all NFL spreads this week.
Below, I’ll make a prediction for this game using football betting odds from BetMGM sportsbook, where football online betting is available.
Seahawks vs. Cardinals Odds
- Seahawks spread: -1.5 (-110)
- Cardinals spread: +1.5 (-110)
- Seahawks moneyline: -125
- Cardinals moneyline: +105
- Total: 43.5 (-110/-110)
Seahawks vs. Cardinals Predictions & Best Bets
In his career, Cardinals quarterback Kyler Murray is just 2-8 against the Seahawks, including 1-5 at home.
Last season, against the Mike Macdonald-led Seahawks, Murray completed 49 of 75 passes (65.3%) for 544 yards (7.3 yards per attempt), two touchdowns, and three interceptions.
To start this season, Murray is averaging just 6.1 yards per attempt.
The Cardinals’ running game is without James Conner for the remainder of the season, as he suffered an ankle injury in Week 3 and will undergo surgery.
Now, it’s all on Trey Benson.
Highlighting the Seahawks’ defence, they are seventh in the NFL in quarterback pressures with 48. When they’ve applied pressure, opposing quarterbacks are completing just 52.6% of their passes for 190 yards (6.2 yards per attempt), two touchdowns, and four interceptions.
When pressured this season, Murray is 10 of 20 (50%) for 161 yards and one interception.
Pivoting to the Cardinals’ defence, they primarily play Cover-3 and Cover-4.
Against those coverages this season, Seahawks quarterback Sam Darnold has completed 32 of 42 passes (76.2%) for 352 yards and one touchdown.
I predict the Seahawks will win and cover the point spread on the road.
What’s the All-Time Head-to-Head Record Between the Seahawks and Cardinals?
The all-time head-to-head record between the Seahawks and Cardinals is 29-22-1, favouring the Seahawks.
What’s the Head-to-Head Record Between the Seahawks and Cardinals in the Playoffs?
The Cardinals and Seahawks have never faced one another in the postseason.
What’s the Longest Winning Streak Between the Seahawks and the Cardinals?
The longest winning streak between the Seahawks and Cardinals is seven games.
The Cardinals have lost their last seven matchup, which have been between Jan. 9, 2022 (Week 18) and Dec. 8, 2024 (Week 14).
When Was the Last Game Between the Seahawks and the Cardinals?
The last game between the Seahawks and Cardinals was on Dec. 8, 2024. The Seahawks won that game 30-18.
What’s the Largest Margin of Victory Between the Seahawks and the Cardinals?
The largest margin of victory between the Seahawks and the Cardinals is 58 points.
The Seahawks beat the Cardinals 58-0 on Dec. 9, 2012.
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