The Buffalo Bills have now won back-to-back games, taking down the Pittsburgh Steelers and the Cincinnati Bengals in Weeks 13 and 14, respectively.
Following their win over the Bengals, the Bills’ odds to win the Super Bowl are +850, fourth in the NFL.
Of all the NFL spreads, none are closer than this week’s game against the New England Patriots.
Below, I’ll cast a prediction for this game using odds from the BetMGM sportsbook, where football betting is available.
Bills vs. Patriots Odds
- Bills spread: -1 (-105)
- Patriots spread: +1 (-115)
- Bills moneyline: -115
- Patriots moneyline: -105
- Total: 49.5 (-110/-110)
Bills vs. Patriots Predictions
This week, the Bills and Patriots will play for the second time, following their first meeting in Week 5.
Heading into this rematch, the Bills’ run defence has stepped up, allowing just 76 rushing yards per game over their last three, second in the NFL in that span.
Additionally, this season they’re holding opposing quarterbacks to 171.8 passing yards, which ranks second in the NFL.
Now, let’s revisit that Week 5 showdown in Buffalo.
Josh Allen and Drake Maye both played well, though Allen’s lone interception led to a Patriots touchdown on the ensuing drive.
Maye didn’t have a passing touchdown, but he didn’t put the ball in harm’s way, and he completed 73.7% of his passes on 30 attempts.
That said, he’s thrown four interceptions over his last six games.
Overall, considering the Bills’ improved run defence, their season-long pass defence, and Maye’s recent interceptions, I predict the Bills edge out a win in Foxborough.
What’s the All-Time Head-to-Head Record Between the Bills and Patriots?
The all-time head-to-head record between the Bills and Patriots is 80-51-1, favouring New England.
What’s the Head-to-Head Record Between the Bills and Patriots in the Playoffs?
The Bills and Patriots are 1-1 in the postseason.
What’s the Longest Winning Streak Between the Bills and the Patriots?
The longest winning streak between the Bills and Patriots is 15 games. The Patriots won these games between 2003 and 2010.
When Was the Last Game Between the Bills and the Patriots?
The last gam between the Bills and Patriots was played on Oct. 5, 2025. The Patriots won 23-20.
What’s the Largest Margin of Victory Between the Bills and the Patriots?
The largest margin of victory between the Bills and Patriots is 46 points. The Patriots beat the Bills 56-10 in 2007.
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