- The 2025 MLB regular season begins between the Dodgers and Cubs in Tokyo on March 15.
- Opening day for the rest of the majors is March 27.
- The Blue Jays are +100 to beat the Orioles in the season opener.
The 2025 MLB regular season officially begins between the Los Angeles Dodgers in Tokyo on March 15.
Opening day in North America is 12 days later, with all 30 teams playing on March 27.
Baseball odds for Opening Day are available at the BetMGM online sportsbook.
2025 MLB Opening Day Odds
| Away Team | Moneyline Odds | Home Team | Moneyline Odds |
| Los Angeles Dodgers | -182 | Chicago Cubs | +150 |
| Milwaukee Brewers | +145 | New York Yankees | -175 |
| Baltimore Orioles | -120 | Toronto Blue Jays | +100 |
| Philadelphia Phillies | -167 | Washington Nationals | +140 |
| Boston Red Sox | +120 | Texas Rangers | -143 |
| San Francisco Giants | +100 | Cincinnati Reds | -120 |
| Pittsburgh Pirates | -167 | Miami Marlins | +140 |
| Cleveland Guardians | +105 | Kansas City Royals | -125 |
| New York Mets | +100 | Houston Astros | -120 |
| Los Angeles Angels | -135 | Chicago White Sox | +115 |
| Atlanta Braves | -110 | San Diego Padres | -110 |
| Minnesota Twins | -120 | St. Louis Cardinals | +100 |
| Detroit Tigers | +125 | Los Angeles Dodgers | -149 |
| Chicago Cubs | +145 | Arizona Diamondbacks | -175 |
| Oakland Athletics | +135 | Seattle Mariners | -161 |
| Colorado Rockies | +180 | Tampa Bay Rays | -222 |
Opening Day MLB Predictions & Best Bets: Thursday, March 27
Blue Jays ML (+100) vs. Orioles
The Baltimore Orioles let Corbin Burnes walk this offseason, leaving Grayson Rodriguez as the likely opening-day starter. The Toronto Blue Jays missed out on Juan Soto and have had an uneventful winter thus far, but this team is far more talented than their 74-win 2024 indicated.
Baltimore finished last season on a 34-38 run. The Orioles were swept by the Kansas City Royals in the wild-card round. In contrast, there were positive signs for the Jays in the second half, including a 22-17 spell from July 21 to Aug. 31.
Toronto will give the ball to either José Berríos, who pitched a gem on opening day in a win over the Tampa Bay Rays last season, or Kevin Gausman, who posted a 2.92 ERA after the All-Star break.
I had a lot of interesting options when making MLB picks today at the BetMGM online sportsbook, but I think the Jays are the pick of the bunch. Toronto might have a slight advantage in the pitching matchup, and their offence is capable of going toe-to-toe with their division rivals at Rogers Centre.
The content provided in this blog is intended for entertainment purposes only. All views and opinions expressed are the authors and reflect their individual perspectives on sports, betting, and related topics. This content should not be considered professional betting advice or the official views of BetMGM LLC. Please gamble responsibly. If you or someone you know is experiencing issues related to gambling, seek help from a licensed health professional. This blog is not liable for any losses, damages, or consequences resulting from betting activities.
